Skip to main content

Psychedelic psychotherapy

For those that remember my post on DMT, here's some interesting news on one of its close relatives:
Here's something a little offbeat for a Friday morning. A team of researchers at the Johns Hopkins School of Medicine has recently documented a safe, long-lasting way of improving both your life and your personal feelings of well-being: shrooms. [...]
Notably, 61% of volunteers considered the psilocybin experience during either or both the [highest dosage] sessions to have been the single most spiritually significant of their lives, with 83% rating it in their top five. Consistent with this, 94% and 89% of volunteers, respectively, indicated that the experiences on those same sessions increased their well-being or life satisfaction and positively changed their behavior at least moderately.

....One month after sessions at either or both the two highest dose sessions, 94% of volunteers endorsed that the experience increased their sense of well-being or life satisfaction moderately or very much, and 89% rated moderate or higher changes in positive behavior. At the 14-month follow-up, these ratings remained high. The types of behavior change most frequently cited by volunteers were better social relationships with family and others, increased physical and psychological self-care, and increased spiritual practice (Table 6). Ratings by community observers before and after the study as well as ratings by study monitors after the study were consistent with the persisting positive changes in behavior and attitudes claimed by the volunteers.

This replicates the results of earlier studies, and it's worth noting that, Eminem songs aside, there have been no recorded cases of death from psilocybin alone, ever.  Here's the structure:

Psilocybin

Like heroin, psilocybin is not actually a drug. Rather it is a prodrug, meaning it is metabolized to an actual drug in the body. In this case, psilocybin is processed into psilocin via dephosphorlyation, meaning your nips off that honkin phosphoryl group up on the top left.  Psilocin is doing the actual psychedelic lifting.

Psilocin

If you'll recall my DMT post, this structure is remarkably similar.  It always astonishes me that substances like psilocin and DMT, with widely varying effects, often differ by only a couple of atoms.  Get rid of that hydroxyl group (the OH on the top left), and you've got DMT.

Comments

Popular posts from this blog

Why Did Reality Winner Leak to the Intercept?

So Reality Winner, former NSA contractor, is in federal prison for leaking classified information — for five years and three months, the longest sentence of any whistleblower in history. She gave documents on how Russia had attempted to hack vendors of election machinery and software to The Intercept , which completely bungled basic security procedures (according to a recent New York Times piece from Ben Smith, the main fault lay with Matthew Cole and Richard Esposito ), leading to her capture within hours. Winner recently contracted COVID-19 in prison, and is reportedly suffering some lingering aftereffects. Glenn Greenwald has been furiously denying that he had anything at all to do with the Winner clusterfuck, and I recently got in an argument with him about it on Twitter. I read a New York story about Winner, which clearly implies that she was listening to the Intercepted podcast of March 22, 2017 , where Greenwald and Jeremy Scahill expressed skepticism about Russia actual...

The Setswana Grammar Manual

One of my few successes during my service here was formatting the Peace Corps South Africa grammar manual for Setswana, written mostly by Art Chambers, an SA16 volunteer.  For anyone wanting to learn Setswana, I reckon it's a pretty good primer, so I present it for free here .  If you think it sucks and you want to make changes, or you'd like to take a look at the raw TeX file, you can find it here .

On Refusing to Vote for Bloomberg

Billionaire Mike Bloomberg is attempting to buy the Democratic nomination. With something like $400 million in personal spending so far, that much is clear — and it appears to be working at least somewhat well, as he is nearing second place in national polls. I would guess that he will quickly into diminishing returns, but on the other hand spending on this level is totally unprecedented. At this burn rate he could easily spend more than the entire 2016 presidential election cost both parties before the primary is over. I published a piece today outlining why I would not vote for Bloomberg against Trump (I would vote for Sanders, Warren, Buttigieg, Klobuchar, or Biden), even though I live in a swing state. This got a lot of "vote blue no matter who" people riled up . They scolded me and demanded that I pre-commit to voting for Bloomberg should he win the nomination. The argument as I understand it is to try to make it as likely as possible that whatever Democrat wins t...