Dimethyltryptamine, or DMT, is a naturally occurring substance sometimes used as a psychedelic drug. It is one of the most famous and widely studied psychedelics (it features in books by McKenna , Shulgin , and Strassman , among others). If you remember the structural shorthand from last week , you should be able to decipher this picture: Dimethyltryptamine (DMT) (By the way, psilocybin, from magic mushrooms, is extremely similar to DMT.) The two commonest methods of administration are smoking and ingesting. The smoking method is sometimes called "the businessman's trip," because it comes on almost immediately and only lasts for 20 minutes or so (compared to LSD's 8-10 hours). The ingesting pathway is a bit more interesting. DMT makes one half of the famous ayahuasca traditional mixture prepared by Amazon shamans. DMT is not normally active orally (it will be metabolized), so one must take a monoamine oxidase inhibitor (MAOI—like harmalin...